Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers
Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers
复制标题
血浆一氧化氮水平作为工厂工人内皮功能障碍的晴雨表
DOI：
10.1055/s-0043-110054
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发表时间：
2017
影响因子：
1.8
通讯作者：
Koike Yasuo
中科院分区：
文献类型：
--
作者：
Miyata Seiko;Noda Akiko;Hara Yuki;Ueyama Jun;Kitaichi Kiyoyuki;Kondo Takaaki;Koike Yasuo
一氧化氮（NO）在调节血管张力中起关键作用，并且被认为是内皮功能障碍的关键标志物之一。我们调查了一氧化氮和危险因素的生活方式相关疾病的工厂workers.MethodsOur研究包括877工厂工人高血压，血脂异常和2型糖尿病。氧化形式的NO，NO2-/NO3-（NOx）血浆浓度测定使用比色法。ResultsNOx血浆水平在患者的生活方式相关的疾病显着低于那些在控制。肱踝脉搏波传导速度（baPWV）在这些患者中测量显着大于对照组。多元回归分析显示，低密度脂蛋白胆固醇是一个独立的危险因素，降低氮氧化物血浆浓度。有趣的是，血浆氮氧化物浓度低的个体比血浆氮氧化物水平高的个体更容易患2型糖尿病（比值比[OR] [95%置信区间; CI]=3.65 [1.61-8.28]，P=0.002，2.67 [1.15-6.20]，P=0.022和3.27 [1.43-7.48]，P=0.005）。血浆氮氧化物水平最低的受试者更容易出现血脂异常（OR [95%CI]=1.69 [1.13-2.53]，P=0.01）.结论血浆氮氧化物评估的内皮功能可能是独立于使用baPWV评估的血管功能的生活方式相关疾病的指示。
ObjectiveNitric oxide (NO) plays a key role in the regulation of vascular tone and is known as one of the key markers of endothelial dysfunction. We investigated the relationship between NO and risk factors of lifestyle-related disease in factory workers.MethodsOur study included 877 factory workers presenting hypertension, dyslipidemia and type 2 diabetes. Oxidated forms of NO, NO2-/NO3- (NOx) plasma concentrations were measured using a colorimetric method.ResultsNOx plasma levels in patients with lifestyle-related disease were significantly lower than those in the controls. The brachial-ankle pulse wave velocity (baPWV) measured in those patients was significantly greater than that of the controls. Multiple regression analysis revealed that LDL cholesterol was an independent risk factor for reducing NOx plasma concentrations. Interestingly, individuals with low NOx plasma concentrations were more likely to present type 2 diabetes compared to those with the highest plasma levels of NOx (odds ratio [OR] [95% confidence interval; CI]=3.65 [1.61–8.28], P=0.002, 2.67 [1.15–6.20], P=0.022, and 3.27 [1.43–7.48], P=0.005). Subjects with the lowest levels of plasma NOx were more likely to present dyslipidemia (OR [95% CI]=1.69 [1.13–2.53], P=0.01).ConclusionEndothelial function evaluated with plasma NOx may be indicative of lifestyle-related diseases independently from the vascular function assessed using baPWV.