Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-γ coactivator-1α and-1β in cultured myotubes
Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-γ coactivator-1α and-1β in cultured myotubes
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DOI：
10.1096/fj.09-133728
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发表时间：
2010-04-01
期刊：
影响因子：
4.8
通讯作者：
Patti, Mary-Elizabeth
中科院分区：
文献类型：
--
作者：
Espinoza, Daniel O.;Boros, Laszlo G.;Patti, Mary-Elizabeth
过氧化物酶体增殖物激活受体γ共激活因子-1（PGC-1）家族是线粒体功能的关键调节因子，mRNA表达降低可能导致肥胖和2型糖尿病患者肌肉脂质蓄积。为了表征PGC-1对脂质代谢的影响，我们使用腺病毒载体在C2 C12肌管中过表达PGC-1 α和PGC-1 β。PGC-1 α和PGC-1 β均增加棕榈酸氧化[31%（P
The peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family is a key regulator of mitochondrial function, and reduced mRNA expression may contribute to muscle lipid accumulation in obesity and type 2 diabetes. To characterize the effects of PGC-1 on lipid metabolism, we overexpressed PGC-1 alpha and PGC-1 beta in C2C12 myotubes using adenoviral vectors. Both PGC-1 alpha and -1 beta increased palmitate oxidation [31% (P