Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1
Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1
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DOI：
10.1016/j.virol.2008.04.033
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发表时间：
2008-08-01
期刊：
影响因子：
3.7
通讯作者：
Duarte dos Santos, Claudia N.
中科院分区：
文献类型：
--
作者：
Bordignon, Juliano;Probst, Christian M.;Duarte dos Santos, Claudia N.
登革热病毒（DENV）感染可引起自限性疾病（登革热）或更严重的临床表现，即登革出血热/登革休克综合征（DSS）。此外，巴西最近登革热流行的数据表明，神经系统症状正变得越来越普遍。然而，登革热的神经发病机制尚不清楚。病毒复制效率和先天免疫之间的平衡——在感染的早期阶段是对立的——决定了DENV感染的临床结果。在这项研究中，我们研究了DENV感染对小鼠中枢神经系统（CNS）转录谱的影响。我们在感染小鼠中观察到151个可能参与登革热神经发病机制的基因上调。相反，它们可能有保护作用。独创性系统软件分析表明，DENV感染在小鼠中枢神经系统中调节的主要途径涉及干扰素信号传导和抗原呈递。(C) 2008爱思唯尔公司版权所有。
Dengue virus (DENV) infection can cause a self-limiting disease (dengue fever) or a more severe clinical presentation known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Furthermore, data from recent dengue epidemics in Brazil indicate that the neurological manifestations are becoming more prevalent. However, the neuropathogenesis of dengue are not well understood. The balance between viral replication efficiency and innate immunity - in opposition during the early stages of infection - determines the clinical outcome of DENV infection. In this study, we investigated the effects of DENV infection on the transcription profile of the central nervous system (CNS) of mice. We observed in infected mice the upregulation of 151 genes possibly involved in neuropathogenesis of dengue. Conversely, they may have a protective effect. Ingenuity Systems software analysis demonstrated, that the main pathways modulated by DENV infection in the mouse CNS are involved in interferon signaling and antigen presentation. (C) 2008 Elsevier Inc. All rights reserved.