AMINO ACID TRANSPORT DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE
AMINO ACID TRANSPORT DURING WORK-INDUCED GROWTH OF SKELETAL MUSCLE
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DOI：
10.1152/ajplegacy.1969.216.5.1111
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发表时间：
1969-01-01
影响因子：
--
通讯作者：
GOODMAN, HM
中科院分区：
文献类型：
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作者：
GOLDBERG, AL;GOODMAN, HM
艾尔·戈德堡和古德曼阁下。工作引起的骨骼肌生长期间的氨基酸运输。是。 J生理学。 216 (5): 1 I1 ll 115. 1969.-在工作诱导的生长过程中，在体内研究了大鼠比目鱼肌和跖肌积累的α-氨基异丁酸(AIB)。腓肠肌的单侧肌腱切断术导致手术肢体的这些肌肉迅速肥大。在生长过程中，肥大的肌肉比对侧对照更大程度地集中 AIB。这种增加在正常、糖尿病和垂体切除大鼠中发现，因此似乎与胰岛素或生长激素无关。在增效剂腱切断后 4 小时，积累明显增加，因此早在可以证明肌肉生长之前。生长停止后，摄取逐渐恢复到控制水平。吸收的增加需要肌肉的工作，并且是腓肠肌协同作用所特有的。在用放线菌素 D 治疗的动物中也发现了类似的变化，尽管这种药物阻碍了生长过程。肌肉肥大；肌肉生长；肌肉工作；锻炼;补偿性生长；胰岛素;生长激素
GOLDBERG, AL, AND HM GOODMAN. Amino acid transport during work-induced growth of skeletal muscle. Am. J Physiol. 216 (5): 1 I1 ll 115. 1969.-The accumulation of a-aminoisobutyric acid (AIB) by the soleus and plantaris muscles of the rat was studied in vivo during work-induced growth. Unilateral tenotomy of the gastrocnemius caused rapid hypertrophy of these muscles of the operated limb. During the growth process, the hypertrophying muscles concentrated AIB to a greater extent than contralateral controls. This increase was found in normal, diabetic, and hypophysectomized rats, and thus appears independent of insulin or growth hormone. Increased accumulation was evident 4 hr after tenotomy of the synergist, and thus long before muscle growth could be demonstrated. After growth had ceased, the uptake gradually returned to control levels. The increase in uptake required muscle work and was specific to the synergists of the gastrocnemius. Similar changes were found in animals treated with actinomycin D, even though this drug blocked the growth process. muscle hypertrophy; muscle growth; muscular work; exercise; compensatory growth; insulin; growth hormone