Anchoring proteins as regulators of signaling pathways.
Anchoring proteins as regulators of signaling pathways.
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DOI：
10.1161/circresaha.111.262899
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发表时间：
2012-08-03
影响因子：
20.1
通讯作者：
Hirsch E
中科院分区：
文献类型：
--
作者：
Perino A;Ghigo A;Scott JD;Hirsch E
信号转导的时空组织是通过在选定的细胞区室中分离信号酶来协调的。这种高度进化的调控机制确保了选中的酶只在其靶蛋白附近被激活。在这种情况下，camp响应性触发蛋白激酶A是由一个称为A激酶锚定蛋白的支架蛋白家族调节的。a激酶锚定蛋白形成多蛋白复合物的核心，并使同时但分离的cAMP信号事件在确定的细胞区室中发生。在这篇综述中，我们将重点描述a激酶锚定蛋白在心脏生理病理调节中的功能。
Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive triggering of protein kinase A is modulated by a family of scaffold proteins referred to as A-kinase anchoring proteins. A-kinase anchoring proteins form the core of multiprotein complexes and enable simultaneous but segregated cAMP signaling events to occur in defined cellular compartments. In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology.