Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-κB and AP-1
Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-κB and AP-1
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DOI：
10.1096/fj.03-0323fje
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发表时间：
2004-01-01
期刊：
影响因子：
4.8
通讯作者：
Shohami, E
中科院分区：
文献类型：
--
作者：
Beni, SM;Kohen, R;Shohami, E
创伤性脑损伤（TBI）后大量产生活性氧（ROS），介导继发性细胞损伤。低分子量抗氧化剂（LMWA）构成了大脑的防御机制之一，其水平与TBI后的结果相关。褪黑激素是主要的松果体激素，具有抗氧化特性。我们研究了褪黑素对闭合性脑损伤（CHI）小鼠神经行为恢复、脑LMWA以及氧化还原敏感性转录因子核因子-κ B（NF-κ B）和AP-1活化的影响。CHI后1h给予褪黑素，至少在1周内促进恢复（P
Traumatic brain injury (TBI) is followed by massive production of reactive oxygen species (ROS), which mediate secondary cellular damage. Low molecular weight antioxidants (LMWA)constitute one of the defense mechanisms of the brain, and their levels correlate with post-TBI outcome. Melatonin, the main pineal hormone, possesses antioxidant properties. We investigated the effects of melatonin on neurobehavioral recovery, brain LMWA, and activation of the redoxsensitive transcription factors nuclear factor-kappaB (NF-kappa B) and AP-1 in mice subjected to closed head injury (CHI). Given 1 h after CHI, melatonin facilitated recovery during at least 1 wk (P