Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
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DOI：
10.1007/s11418-006-0041-7
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Hattori, Masao
中科院分区：
文献类型：
--
作者：
Jo, Michiko;Nakamura, Norio;Hattori, Masao
For the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp.
