High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine)
High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine)
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DOI：
10.1016/j.biomaterials.2007.03.010
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发表时间：
2007-07-01
期刊：
影响因子：
14
通讯作者：
Ishihara, Kazuhiko
中科院分区：
文献类型：
--
作者：
Kyomoto, Masayuki;Iwasaki, Yasuhiko;Ishihara, Kazuhiko
人工髋关节中聚乙烯的磨损颗粒引起的骨溶解是一个值得关注的问题。已经尝试了各种轴承联接组合、轴承材料改进和表面改性来减少这种磨损颗粒。为了减少磨损并开发新型人工髋关节系统，我们创建了一种高度润滑的金属轴承材料：将2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）聚合物接枝到钴-铬-钼（Co-Cr-Mo）合金表面。为了确保聚（MPC）在Co-Cr-Mo合金上的长期保留，我们使用4-甲基丙烯酰氧基乙基偏苯三酸酐（4-Meta）中间层和光诱导接枝聚合技术，以通过4-Meta层在Co-Cr-Mo基底和聚（MPC）链之间产生强键合。采用硝酸和氧等离子体对Co-Cr-Mo合金进行预处理，以促进4-Meta羧基与Co-Cr-Mo合金表面Cr氧化物钝化层上的羟基之间的有效相互作用。MPC接枝后，在Co-Cr-Mo表面的衰减全反射傅里叶变换红外光谱（FT-IR/ATR）和X射线光电子能谱（XPS）中观察到MPC单元峰。摩擦学研究与销板机显示，表面MPC接枝显着降低摩擦系数。我们得出结论，接枝聚（MPC）层成功地提供了高润滑性的钴-铬-钼表面。(c)2007爱思唯尔有限公司保留所有权利。
Osteolysis caused by wear particles from polyethylene in artificial hip joints is of great concern. Various bearing couple combinations, bearing material improvements, and surface modifications have been attempted to reduce such wear particles. With the aim of reducing the wear and developing a novel artificial hip-joint system, we created a highly lubricious metal-bearing material: A 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was grafted onto the surface of the cobalt-chromium-molybdenum (Co-Cr-Mo) alloy. For ensuring the long-term retention of poly(MPC) on the Co-Cr-Mo alloy, we used a 4-methacryloxyethyl trimellitate anhydride (4-META) intermediate layer and photo-induced graft polymerization technique to create a strong bonding between the Co-Cr-Mo substrate and the poly(MPC) chain via the 4-META layer. The Co-Cr-Mo alloy was pretreated with nitric acid and O-2 plasma to facilitate efficient interaction between the 4-META carboxyl group and the surface hydroxyl group on the Cr oxide passive layer of the Co-Cr-Mo alloy. After MPC grafting, the MPC unit peaks were clearly observed in the Fourier-transform infrared spectroscopy with attenuated total reflection (FT-IR/ATR) and X-ray photoelectron spectroscopy (XPS) spectra of the Co-Cr-Mo surface. Tribological studies with a pin-on-plate machine revealed that surface MPC grafting markedly lowered the friction coefficient. We concluded that the grafted poly(MPC) layer successfully provided high lubricity to the Co-Cr-Mo surface. (c) 2007 Elsevier Ltd. All rights reserved.