ON THE MODE OF BAKERS-YEAST REDUCTION OF METHYL-SUBSTITUTED ARYLALKYL-GAMMA AND DELTA-KETO ACIDS - SYNTHESIS OF CIS-(+)-ROSE OXIDE
ON THE MODE OF BAKERS-YEAST REDUCTION OF METHYL-SUBSTITUTED ARYLALKYL-GAMMA AND DELTA-KETO ACIDS - SYNTHESIS OF CIS-(+)-ROSE OXIDE
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DOI：
10.1016/s0040-4020(01)88272-7
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发表时间：
1992-08-28
期刊：
影响因子：
2.1
通讯作者：
TERRENI, M
中科院分区：
文献类型：
--
作者：
FRONZA, G;FUGANTI, C;TERRENI, M
Baker‘s酵母还原甲基取代的伽马-和三角洲-酮酸1-6的方式取决于微妙的底物结构改变；它提供中等ee和de值的伽马-内酯和高度官能化的、对映体纯的三角洲-内酯，例如13，从中制备顺式-(+)-玫瑰氧化物23a。
Baker's yeast reduction of methyl substituted gamma-and delta-keto acids 1-6 proceeds in a mode depending upon subtle substrate structural modifications; it affords gamma-lactones of modest ee and de values and highly functionalized, enantiomerically pure delta-lactones, such as 13 from which cis-(+)-rose oxide 23a has been prepared.