Prenatal exposure to recreational drugs affects global motion perception in preschool children.
Prenatal exposure to recreational drugs affects global motion perception in preschool children.
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DOI：
10.1038/srep16921
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发表时间：
2015-11-19
影响因子：
4.6
通讯作者：
Thompson B
中科院分区：
文献类型：
--
作者：
Chakraborty A;Anstice NS;Jacobs RJ;LaGasse LL;Lester BM;Wouldes TA;Thompson B
产前暴露于娱乐性药物会损害运动和认知发育;然而，目前尚不清楚视觉脑区是否受到影响。为了解决这个问题，我们研究了产前药物暴露对整体运动知觉的影响，这是一种被认为特别容易受到异常神经发育影响的背侧纹外视皮层内处理的行为测量。在145名4.5岁的儿童中测量了整体运动感知，这些儿童在出生前接触过甲基苯丙胺，酒精，尼古丁和大麻的不同组合，25名未接触过的儿童。母亲自我报告的药物使用情况通过胎粪分析进行验证。我们发现，产前接触酒精会损害整体运动知觉，而接触大麻会显著改善整体运动知觉。产前暴露于这两种药物没有影响。其他视觉功能，如习惯性视敏度和立体视敏度不受药物暴露的影响。产前接触甲基苯丙胺不会影响视觉功能。我们的研究结果表明，产前药物暴露可以影响视觉发育的行为措施，但效果取决于怀孕期间使用的特定药物。
Prenatal exposure to recreational drugs impairs motor and cognitive development; however it is currently unknown whether visual brain areas are affected. To address this question, we investigated the effect of prenatal drug exposure on global motion perception, a behavioural measure of processing within the dorsal extrastriate visual cortex that is thought to be particularly vulnerable to abnormal neurodevelopment. Global motion perception was measured in one hundred and forty-five 4.5-year-old children who had been exposed to different combinations of methamphetamine, alcohol, nicotine and marijuana prior to birth and 25 unexposed children. Self-reported drug use by the mothers was verified by meconium analysis. We found that global motion perception was impaired by prenatal exposure to alcohol and improved significantly by exposure to marijuana. Exposure to both drugs prenatally had no effect. Other visual functions such as habitual visual acuity and stereoacuity were not affected by drug exposure. Prenatal exposure to methamphetamine did not influence visual function. Our results demonstrate that prenatal drug exposure can influence a behavioural measure of visual development, but that the effects are dependent on the specific drugs used during pregnancy.