The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor -: art. no. e65
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor -: art. no. e65
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DOI：
10.1136/jmg.2005.035568
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发表时间：
2005-11-01
影响因子：
4
通讯作者：
Bonifati, V
中科院分区：
文献类型：
--
作者：
Goldwurm, S;Di Fonzo, A;Bonifati, V
背景：富含亮氨酸重复激酶 2 (LRRK2) 基因的突变最近被确定为 PARK8 连锁常染色体显性帕金森病的病因。 目的：研究来自意大利的大样本患者中复发的 LRRK2 突变，包括早期 (
Background: Mutations in the gene Leucine-Rich Repeat Kinase 2 (LRRK2) were recently identified as the cause of PARK8 linked autosomal dominant Parkinson's disease.Objective: To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (