Three-dimensional conductive constructs for nerve regeneration
Three-dimensional conductive constructs for nerve regeneration
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DOI：
10.1002/jbm.a.32226
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发表时间：
2009-11-01
影响因子：
4.9
通讯作者：
Kohane, Daniel S.
中科院分区：
文献类型：
--
作者：
George, Paul M.;Saigal, Rajiv;Kohane, Daniel S.
导电聚合物的独特电化学性质可用于形成独立的聚合物管和管阵列，其适用于引导以促进周围神经再生。非复合材料，聚吡咯（PPy）管的内径从25 μ m到1.6毫米，以及多通道管制造的电沉积。虽然吡咯单体的氧化导致膜的生长，但随后的短暂还原允许从电极模具机械解离，产生独立的导电PPy管。将以这种方式制成的导电聚合物神经导管放置在横断的大鼠坐骨神经中，并显示在8周的时间段内支持神经再生。(C)2008 Wiley Periodicals，Inc. J Biomed Mater Res 91A：519-527，2009
The unique electrochemical properties of conductive polymers can be utilized to form stand-alone polymeric tubes and arrays of tubes that are suitable for guides to promote peripheral nerve regeneration. Noncomposite, polypyrrole (PPy) tubes ranging in inner diameter from 25 mu m to 1.6 mm as well as multichannel tubes were fabricated by electrodeposition. While oxidation of the pyrrole monomer causes growth of the film, brief Subsequent reduction allowed mechanical dissociation from the electrode mold, creating a stand-alone, conductive PPy tube. Conductive polymer nerve guides made in this manner were placed in transected rat sciatic nerves and shown to support nerve regeneration over an 8-week time period. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 519-527, 2009