Inflammatory activity assessment by F18 FDG-PET/CT in persistent symptomatic sarcoidosis
Inflammatory activity assessment by F18 FDG-PET/CT in persistent symptomatic sarcoidosis
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DOI：
10.1016/j.rmed.2011.08.012
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发表时间：
2011-12-01
影响因子：
4.3
通讯作者：
Drent, M.
中科院分区：
文献类型：
--
作者：
Mostard, R. L. M.;Voo, S.;Drent, M.
背景：在有持续致残症状的结节病患者中确定炎性活动是重要的。全身F-18-FDG PET/CT（PET）似乎是检测新诊断的症状性结节病炎症活动的敏感方法。其目的是评估使用PET在结节病患者不明原因的持续致残症状和PET结果和血清学炎症markers.Methods之间的关联炎症活动的存在：结节病患者谁接受了PET 2005年6月至2010年6月（n = 89），回顾性纳入。检查了所有PET扫描，阳性结果被分类为胸部和/或胸外。血管紧张素转换酶（ACE），可溶性白细胞介素-2受体（sIL-2 R），和neopterinewere considered.Results：在65/89（73%）的研究患者PET是阳性的，其中52（80%）有炎症活动的血清学体征。在14/15例胸部X线IV期PET阳性的患者中。在PET阳性的患者中，80%的患者存在胸外炎性活动，联合血清学炎症标志物对PET检测炎性活动的敏感性为80%，特异性为100%，阳性预测值为100%，阴性预测值为65%。大多数具有持续致残症状的结节病患者，即使是放射学IV期患者，PET阳性结果明显为80%的胸外病变。在20%的PET是阳性的，没有血清学炎症活动的迹象。PET似乎是额外的价值，以评估炎症活动的症状持续存在的患者在没有迹象的血清学炎症活动和检测胸外病变。(C)2011爱思唯尔有限公司版权所有。
Background: Establishing inflammatory activity in sarcoidosis patients with persistent disabling symptoms is important. Whole body F-18-FDG PET/CT (PET) appeared to be a sensitive method to detect inflammatory activity in newly diagnosed symptomatic sarcoidosis. The aim was to assess the presence of inflammatory activity using PET in sarcoidosis patients with unexplained persistent disabling symptoms and the association between PET findings and serological inflammatory markers.Methods: Sarcoidosis patients who underwent a PET between June 2005 and June 2010 (n = 89), were retrospectively included. All PET scans were examined and positive findings were classified as thoracic and/or extrathoracic. As serological markers of inflammatory activity angiotensine-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), and neopterine were considered.Results: In 65/89 (73%) of the studied patients PET was positive, 52 of them (80%) had serological signs of inflammatory activity. In 14/15 patients with a Chest X-ray stage IV PET was positive. In 80% of the PET positive patients extrathoracic inflammatory activity was found. Sensitivity of combined serological inflammatory markers for the presence of inflammatory activity as detected by PET was 80%, specificity 100%, positive predictive value 100%, negative predictive value 65%.Conclusions: The majority of sarcoidosis patients with persistent disabling symptoms, even those with radiological stage IV, had PET positive findings with remarkably 80% extrathoracic lesions. In 20% PET was positive without signs of serological inflammatory activity. PET appeared to be of additional value to assess inflammatory activity in patients with persistent symptoms in the absence of signs of serological inflammatory activity and to detect extrathoracic lesions. (C) 2011 Elsevier Ltd. All rights reserved.