Estimating the relative contributions of maternal genetic, paternal genetic and intrauterine factors to offspring birth weight and head circumference
Estimating the relative contributions of maternal genetic, paternal genetic and intrauterine factors to offspring birth weight and head circumference
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DOI：
10.1016/j.earlhumdev.2010.05.021
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发表时间：
2010-07-01
影响因子：
2.5
通讯作者：
Thapar, Anita
中科院分区：
文献类型：
--
作者：
Rice, Frances;Thapar, Anita
背景：遗传因素和产前环境影响出生体重。然而，很少有类型的研究设计能够理清它们的相对贡献。目的：检查母亲遗传和子宫内对后代出生体重和头围的影响。比较母本和父本遗传效应的贡献。 研究设计：母亲和父亲与其通过体外受精受孕的后代有遗传相关或无关。 受试者： 423 个单胎足月后代，其中 262 个通过同源 IVF 受孕（父母均相关），66 个通过捐精受孕（仅与母亲相关），95 个通过捐卵受孕（仅与父亲相关）。 措施：产前预约时的母亲体重、当前体重和母亲身高。父亲当前的体重和身高都是预测因素。婴儿出生体重和头围是结果。结果：遗传相关性是父母体重和后代出生体重测量之间的主要影响因素，因为只有当父母与孩子有血缘关系时，相关性才显着。然而，子宫内环境对母亲身高与婴儿出生体重和婴儿头围之间的关联有一定影响，因为即使母亲与孩子没有血缘关系，这些关系也很重要。结论：母亲和父亲基因都对婴儿出生体重有贡献。母亲身高似乎表明了子宫内环境对婴儿生长和胎龄的影响。结果表明，子宫内环境和母体遗传特征之间可能存在生物相互作用，从而抑制了父体基因的影响。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Background: Genetic factors and the prenatal environment contribute to birth weight. However, very few types of study design can disentangle their relative contribution.Aims: To examine maternal genetic and intrauterine contributions to offspring birth weight and head circumference. To compare the contribution of maternal and paternal genetic effects.Study design: Mothers and fathers were either genetically related or unrelated to their offspring who had been conceived by in vitro fertilization.Subjects: 423 singleton full term offspring, of whom 262 were conceived via homologous IVF (both parents related), 66 via sperm donation (mother only related) and 95 via egg donation (father only related).Measures: Maternal weight at antenatal booking, current weight and maternal height. Paternal current weight and height were all predictors. Infant birth weight and head circumference were outcomes.Results: Genetic relatedness was the main contributing factor between measures of parental weight and offspring birth weight as correlations were only significant when the parent was related to the child. However, there was a contribution of the intrauterine environment to the association between maternal height and both infant birth weight and infant head circumference as these were significant even when mothers were unrelated to their child.Conclusions: Both maternal and paternal genes made contributions to infant birth weight. Maternal height appeared to index a contribution of the intrauterine environment to infant growth and gestational age. Results suggested a possible biological interaction between the intrauterine environment and maternal inherited characteristics which suppresses the influence of paternal genes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.