Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima.
Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima.
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Neopetrosiquinones A 和 B，从深水海绵 Neopetrosia 中分离出的倍半萜苯醌 cf.
DOI：
10.1016/j.bmc.2011.09.026
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发表时间：
2011
影响因子：
3.5
通讯作者：
Wright,AmyE
中科院分区：
文献类型：
--
作者：
Winder,PriscillaL;Baker,HeatherL;Linley,Patricia;Guzmán,EstherA;Pomponi,ShirleyA;Diaz,MCristina;Reed,JohnK;Wright,AmyE
从岩藻科（Petrosiidae）的一种深水海绵中分离得到两个新的倍半萜苯醌类化合物，命名为neopetrosiquinone A（1）和B（2）。根据光谱数据鉴定了化合物的结构。化合物1和2抑制DLD-1人结直肠腺癌细胞系的体外增殖，IC 50值分别为3.7和9.8μM，抑制PANC-1人胰腺癌细胞系的体外增殖，IC 50值分别为6.1和13.8μM。新番荔枝醌A（1）对人胰腺癌细胞株AsPC-1的体外增殖也有抑制作用，IC_（50）值为6.1μM。这些化合物在结构上与alisiaquinone A、cyclozonarone和xestoquinone相关。
Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC50values of 3.7 and 9.8μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC50values of 6.1 and 13.8μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC50value of 6.1μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.