RISK OF FEBRILE SEIZURES IN CHILDHOOD IN RELATION TO PRENATAL MATERNAL CIGARETTE-SMOKING AND ALCOHOL INTAKE
RISK OF FEBRILE SEIZURES IN CHILDHOOD IN RELATION TO PRENATAL MATERNAL CIGARETTE-SMOKING AND ALCOHOL INTAKE
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DOI：
10.1093/oxfordjournals.aje.a115681
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发表时间：
1990-09-01
影响因子：
5
通讯作者：
FARWELL, JR
中科院分区：
文献类型：
--
作者：
CASSANO, PA;KOEPSELL, TD;FARWELL, JR
本文介绍的儿童热性惊厥的病例对照研究，包括472对病例对照，在美国华盛顿西部，旨在调查产前暴露作为热性惊厥危险因素的重要性，并确定两种临床亚型(简单和复杂)热性惊厥具有不同危险因素的程度。母亲在怀孕期间吸烟和饮酒与儿童发热性癫痫发作的风险有关。产前吸烟与单纯性发热性癫痫的风险增加两倍相关(95%可信区间1.2-3.4)，并且存在很强的剂量-反应关系。这种联系不能用母亲人口统计变量、母亲酒精摄入量、婴儿S出生体重或儿童病史变量来解释。产前母亲饮酒与复杂发热性癫痫发作风险增加两倍相关(95%可信区间1.3-3.8)，并且存在很强的剂量-反应关系。这种联系不能用母亲年龄、种族、教育或吸烟来解释。这些结果表明，在怀孕期间减少吸烟和饮酒也可能是预防儿童热性癫痫发作的有效方法。
The case-control study of febrile seizures in childhood described here, comprising 472 case-control pairs in western Washington (USA) was designed to investigate the importance of prenatal exposures as risk factors for febrile seizures and to determine the degree to which two clinical subtypes of febrile seizures (simple and complex) have different risk factors. Maternal cigarette smoking and alcohol intake during pregnancy were associated with the risk of a febrile seizure in the child. Prenatal maternal cigarette smoking was associated with a twofold increase in the risk of a simple febrile seizure (95% confidence interval 1.2-3.4), and a strong dose-response relation was found. This association could not be explained by maternal demographic variables, maternal alcohol intake, child''s birth weight, or childhood medical history variables. Prenatal maternal alcohol intake was associated with a twofold increase in the risk of a complex febrile seizure (95% confidence interval 1.3-3.8), and a strong dose-response relation was present. This association could not be explained by maternal age, race, education, or cigarette smoking. These results suggest that curtailment of smoking and alcohol consumption during pregnancy, a measure already widely prescribed during pregnancy, may also be an effective means of preventing childhood febrile seizures.