Abnormal regional homogeneity of drug-naı¨ve obsessive-compulsive patients
Abnormal regional homogeneity of drug-naı¨ve obsessive-compulsive patients
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DOI：
10.1097/wnr.0b013e32833cadf0
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发表时间：
2010-08
期刊：
影响因子：
1.7
通讯作者：
Tao Yang;Yuqi Cheng;Haijun Li;Hongyan Jiang;C. Luo;B. Shan;Lin Xu;Xiufeng Xu
中科院分区：
文献类型：
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作者：
Tao Yang;Yuqi Cheng;Haijun Li;Hongyan Jiang;C. Luo;B. Shan;Lin Xu;Xiufeng Xu
为探讨强迫症（OCD）患者可能存在的静息态活动异常，计算了22对强迫症患者和配对的健康对照者的静息态活动区域同质性（ReHo）。与对照组相比，患者左侧扣带回前部的ReHo明显升高，而左侧颞下回的ReHo明显降低。这些发现支持了药物初治强迫症患者的异常静息态脑活动。ReHo值与强迫症的4项临床特征均无显著相关性，提示强迫症患者的ReHo值异常可能与强迫症的4项临床特征有关。
To explore the possible abnormal resting-state activity in patients with obsessive-compulsive disorder (OCD), the regional homogeneity (ReHo) of 22 pairs of patients and well-matched healthy controls was calculated. Compared with controls, the patients showed higher ReHo in the left anterior cingulate cortex, but lower ReHo in the left inferior temporal gyrus. These findings supported the abnormal resting-state brain activity in drug-naïve OCD patients. No significant correlations between ReHo value and four clinical characteristics were found, suggesting that abnormal ReHo might be trait-related in OCD.