QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies
QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies
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DOI：
10.7326/0003-4819-155-8-201110180-00009
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发表时间：
2011-10-18
影响因子：
39.2
通讯作者：
Bossuyt, Patrick M. M.
中科院分区：
文献类型：
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作者：
Whiting, Penny F.;Rutjes, Anne W. S.;Bossuyt, Patrick M. M.
2003年，开发了用于系统审查诊断准确性研究的QUADAS工具。经验，轶事报告和反馈建议的改进领域；因此，开发了QUADAS-2。该工具包括4个领域：患者选择、索引测试、参考标准、流程和时机。每个领域都根据偏差风险进行评估，前3个领域也根据适用性进行评估。信号问题包括帮助判断偏见的风险。QUADAS-2工具的应用分为4个阶段：总结综述问题、定制工具并生成针对综述的指导、构建初步研究的流程图、判断偏差和适用性。该工具将允许更透明的偏见评级和初级诊断准确性研究的适用性。
In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias.The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.