A complex oscillating network of signaling genes underlies the mouse segmentation clock
A complex oscillating network of signaling genes underlies the mouse segmentation clock
复制标题
DOI：
10.1126/science.1133141
复制
发表时间：
2006-12-08
期刊：
影响因子：
56.9
通讯作者：
Pourquie, Olivier
中科院分区：
文献类型：
--
作者：
Dequeant, Mary-Lee;Glynn, Earl;Pourquie, Olivier
脊椎的节段性模式是在发育早期建立起来的，此时脊椎前体，即体节，是从卵裂期前的中胚层有节奏地产生的。对小鼠有丝分裂前中胚层转录组的微阵列研究表明，与这一过程相关的振荡器，即分段时钟，驱动参与细胞信号传递的大型循环基因网络的周期性表达。在每个周期中，缺口成纤维细胞生长因子和Wnt通路的相互排斥激活表明，这三个通路的协调调节是时钟振荡器的基础。
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch-fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.