Role of bacterial vaginosis-associated microorganisms in endometritis
Role of bacterial vaginosis-associated microorganisms in endometritis
复制标题
DOI：
10.1016/s0002-9378(96)70158-8
复制
发表时间：
1996-08-01
影响因子：
9.8
通讯作者：
Holmes, KK
中科院分区：
文献类型：
--
作者：
Hillier, SL;Kiviat, NB;Holmes, KK
目的：我们的目标是确定细菌性阴道病和细菌性阴道病相关的微生物的作用，在patientis.Study设计：子宫内膜活检组织学和微生物的研究，从178个连续的妇女怀疑盆腔炎性疾病，其中85人进行腹腔镜检查，以诊断salpingitis.Results：组织学patientis 117（65%）的妇女被证实。在接受腹腔镜检查的妇女中，输卵管炎在68%的输卵管炎患者和23%的无输卵管炎患者中存在。一些但不是所有的细菌性阴道病相关微生物与尿道炎有关。通过逻辑回归分析，在调整细菌性阴道病和淋病奈瑟菌和沙眼衣原体分离后，子宫内膜炎与子宫内膜N。淋病（优势比5.7，95%可信区间1.8 ~ 17.5）、C.沙眼衣原体（优势比4.8，95%可信区间1.3 ~ 18.2）、厌氧性革兰氏阴性杆菌（优势比2.6，95%可信区间1.1 ~ 5.7）和非白种人（优势比2.3，95%可信区间1.1 ~ 4.8）。gonorrhoeae和C.沙眼，支持这些微生物在临床疑似盆腔炎性疾病妇女组织学盆腔炎病因学中的作用。
OBJECTIVE: Our goal was to define the role of bacterial vaginosis and bacterial vaginosis-associated microorganisms in endometritis.STUDY DESIGN: Endometrial biopsies were obtained for histologic and microbiologic study from 178 consecutive women with suspected pelvic inflammatory disease, and 85 of them underwent laparoscopy to diagnose salpingitis.RESULTS: Histologic endometritis was confirmed in 117 (65%) of the women. Among women who underwent laparoscopy, salpingitis was present in 68% of those with and 23% of those without endometritis. Some but not all bacterial vaginosis-associated microorganisms were linked with endometritis. By logistic regression analysis, after adjustment for bacterial vaginosis and isolation of Neisseria gonorrhoeae and Chlamydia trachomatis, endometritis was associated with endometrial N. gonorrhoeae (odds ratio 5.7, 95% confidence interval 1.8 to 17.5), C. trachomatis (odds ratio 4.8, 95% confidence interval 1.3 to 18.2), anaerobic gram-negative rods (odds ratio 2.6, 95% confidence interval 1.1 to 5.7), and nonwhite race (odds ratio 2.3, 95% confidence interval 1.1 to 4.8).CONCLUSIONS: The association of anaerobic gram-negative rods with endometritis, after adjustment for bacterial vaginosis, N. gonorrhoeae, and C. trachomatis, supports the role of these microorganisms in the etiology of histologic endometritis among women with clinically suspected pelvic inflammatory disease.