Hemorrhagic shock and the central vasopressin and opioid peptide system of rats.
Hemorrhagic shock and the central vasopressin and opioid peptide system of rats.
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大鼠失血性休克与中枢加压素和阿片肽系统。
DOI：
10.1152/ajpendo.1985.249.3.e244
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Faden,AI
中科院分区：
文献类型：
--
作者：
Feuerstein,G;Molineaux,CJ;Rosenberger,JG;Zerbe,RL;Cox,BM;Faden,AI
本文观察了失血性休克(占血容量的40%)对清醒大鼠垂体和脑内强啡肽A(dynA-IR)、[Arg8]加压素(AVP-IR)和[Leu5]脑啡肽(LE-IR)分布的影响。出血后24 h，神经中间叶(NIL)Dyn A-IR减少(52%)，AVP-IR减少(32%)，LE-IR增加(72%)，前叶Dyn A-IR减少(50%)，LE-IR增加(210%)。与正常对照组相比，各实验组大鼠前脑部分核团中的Dyn A-IR显著减少，而下丘脑腹内侧核中的Dyn A-IR仅在假对照组显著升高。出血后2小时和24小时，视上核和正中隆起的AVP-IR升高(分别为200%和31%)，但血浆AVP恢复到正常水平。这些数据表明，应激和低血容量性低血压引起中枢神经系统强啡肽、AVP和LE分布的部位和时间依赖性改变。
The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat. At 24 h after hemorrhage, the neurointermediate lobe (NIL) showed a reduction in Dyn A-IR (52%) and AVP-IR (32%) and an increase in LE-IR (72%); at this time, the anterior lobe also showed decreased Dyn A-IR (50%) and increased LE-IR (210%). Dyn A-IR, but not LE-IR, was also significantly depleted in some forebrain nuclei in all experimental groups as compared with intact controls, whereas Dyn A-IR in the hypothalamic ventromedial nucleus was elevated only in the sham-control rats. AVP-IR was elevated in the supraoptic nucleus and median eminence (200 and 31%, respectively) 2 and 24 h after bleeding, although plasma AVP returned to normal levels. These data indicate that stress and hypovolemic hypotension produce site and time-dependent change in distribution of dynorphins, AVP, and LE in the central nervous system.
DOI：
--
发表时间：
1982
期刊：
Life Science
影响因子：
--
作者：
B. Cox
通讯作者：
B. Cox