Sticking to a plan: adhesion and signaling control spatial organization of cells within migrating collectives.
Sticking to a plan: adhesion and signaling control spatial organization of cells within migrating collectives.
复制标题
坚持计划：粘附和信号传导控制迁移集体内细胞的空间组织。
DOI：
10.1016/j.gde.2019.07.003
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发表时间：
2019
影响因子：
4
通讯作者：
Stathopoulos,Angelike
中科院分区：
文献类型：
--
作者：
Macabenta,Frank;Stathopoulos,Angelike
大量的生物现象需要集体细胞迁移，包括器官发生和胚胎发育。集体细胞迁移的机制不仅涉及与单细胞迁移相关的形态发生变化，而且还需要在运动过程中维持细胞与细胞的连接。此外，细胞形状的变化和极性必须以多细胞方式协调，以保持迁移群体的定向运动，并且通常与常见信号通路的多种功能相关。在这篇综述中，我们总结了目前对迁移过程中高阶组织组织机制的理解，特别关注细胞粘附和信号之间的相互作用，我们建议可以调整这些信号以支持不同类型的集体运动。
Collective cell migration is required in a vast array of biological phenomena, including organogenesis and embryonic development. The mechanisms that underlie collective cell migration not only involve the morphogenetic changes associated with single cell migration, but also require the maintenance of cell–cell junctions during movement. Additionally, cell shape changes and polarity must be coordinated in a multicellular manner in order to preserve directional movement in the migrating cohort, and often relates to multiple functions of common signaling pathways. In this review, we summarize the current understanding of the mechanisms underlying higher order tissue organization during migration, with particular focus on the interplay between cell adhesion and signaling that we propose can be tuned to support different types of collective movements.