INTRAVENTRICULAR CORTICOSTERONE INCREASES THE RATE OF BODY-WEIGHT GAIN IN UNDERWEIGHT ADRENALECTOMIZED RATS
INTRAVENTRICULAR CORTICOSTERONE INCREASES THE RATE OF BODY-WEIGHT GAIN IN UNDERWEIGHT ADRENALECTOMIZED RATS
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DOI：
10.1210/en.130.1.269
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发表时间：
1992-01-01
期刊：
影响因子：
4.8
通讯作者：
WOODS, SC
中科院分区：
文献类型：
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作者：
GREEN, PK;WILKINSON, CW;WOODS, SC
循环糖皮质激素对肥胖啮齿动物的贪食和体重过度增加是必要的。据报道，经脑室内注射选定的糖皮质激素可恢复厌食症切除肾上腺的金硫葡萄糖处理小鼠的贪食和体重增加。我们想确定糖皮质激素直接进入正常（非肥胖）大鼠的中枢神经系统是否会提高体重增加的速度。在最初的实验中，允许大鼠自由进食或通过7至10天的食物限制使其体重过轻。然后将动物的肾上腺切除或假手术，并允许它们随意进食。两组肾上腺切除的动物比它们各自的假对照组消耗更少的食物，体重增加的速度也更慢。先前受食物限制、因此体重过轻的肾上腺切除大鼠比先前随意喂食的肾上腺切除大鼠消耗了更多的食物，体重增加得更快。这些数据支持这样的结论，即肾上腺切除的大鼠和完整的大鼠一样，可以调节它们的体重，尽管其水平低于完整的大鼠。为了确定中枢糖皮质激素在这种现象中的可能作用，在肾上腺切除术或假手术后的第二天，限制食物或随意喂养的大鼠接受单次脑室内注射皮质酮或其载体。尽管脑室内皮质酮对自由喂养大鼠的体重增加没有影响，但相对于给药的对照组，它显著增加了限制食物的肾上腺切除大鼠的体重增加速度。在这种情况下，外周给药皮质酮没有效果。由此可见，糖皮质激素可直接作用于体重过轻的瘦大鼠中枢神经系统，从而增加体重。
Circulating glucocorticoids are necessary for hyperphagia and excessive weight gain in obese rodents. It has been reported that intraventricular administration of selected glucocorticoids restores hyperphagia and weight gain in anorexic adrenalectomized gold thioglucose-treated mice. We wanted to determine whether administration of glucocorticoids directly into the central nervous system of normal (nonobese) rats will enhance the rate of weight gain. In the initial experiment rats were allowed ad libitum access to chow or were rendered under-weight by a 7- to 10-day period of food restriction. Animals were then adrenalectomized or sham operated and allowed ad libitum access to chow. Both groups of adrenalectomized animals consumed less food and gained weight less rapidly than their respective sham controls. Previously food-restricted and therefore underweight adrenalectomized rats consumed significantly more food and gained weight more rapidly than previously ad libitum-fed adrenalectomized rats. These data support the conclusion that adrenalectomized rats, like intact rats, regulate their weight, albeit at a lower level than intact rats. To determine a possible role of central glucocorticoids in this phenomenon, food-restricted or ad libitum-fed rats received a single intraventricular injection of corticosterone or its vehicle on the day after adrenalectomy or sham surgery. Whereas intraventricular corticosterone had no effect on weight gain in ad libitum-fed rats, it significantly increased the rate of weight gain in food-restricted adrenalectomized rats relative to that in vehicle-treated controls. Peripheral administration of corticosterone had no effect in this paradigm. It is concluded that glucocorticoids act directly on the central nervous system of underweight lean rats to augment weight gain.