5-HT(1A) autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei: effects on circadian clock resetting.
5-HT(1A) autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei: effects on circadian clock resetting.
复制标题
5-HT（1A）自身受体拮抗剂诱导仓鼠视交叉上核中的 5-HT 释放：对生物钟重置的影响。
DOI：
10.1016/s0304-3940(00)00873-9
复制
发表时间：
2000
影响因子：
2.5
通讯作者：
Mistlberger,RE
中科院分区：
文献类型：
--
作者：
Antle,MC;Glass,JD;Mistlberger,RE
血清素 (5-HT) 与非光刺激引起的哺乳动物昼夜节律的相移有关。本研究测试药物诱导内源性 5-HT 释放是否可以改变叙利亚仓鼠的昼夜节律阶段。在主观日中期全身注射 5-HT1A 拮抗剂 WAY100635 可使仓鼠视交叉上核 (SCN) 昼夜节律起搏器透析液中的 5-HT 显着增加约 50%，持续 40-60 分钟。然而，这与相移或 3 小时跑步引起的相移增强无关。这些结果表明，SCN 或可能其他区域中增强的 5-HT 释放不足以诱导主观日的相移。
Serotonin (5-HT) has been implicated in phase shifting of mammalian circadian rhythms by non-photic stimuli. This study tests whether pharmacological induction of endogenous 5-HT release can shift circadian phase in the Syrian hamster. Systemic injections of the 5-HT1Aantagonist WAY100635 during the mid-subjective day significantly increased 5-HT in dialysate from the hamster suprachiasmatic nucleus (SCN) circadian pacemaker by ∼50% for 40–60 min. However, this was not associated with phase shifts or with potentiation of phase shifts induced by a 3 h bout of running. These results indicate that enhanced 5-HT release in the SCN or possibly other regions is not sufficient to induce phase shifts in the subjective day.