Interactions of nanomaterials with cell signalling systems-Focus on purines-mediated pathways
Interactions of nanomaterials with cell signalling systems-Focus on purines-mediated pathways
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DOI：
10.1016/j.colsurfb.2022.112919
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发表时间：
2022-10-14
影响因子：
5.8
通讯作者：
Roszek，Katarzyna
中科院分区：
文献类型：
--
作者：
Ficerman，Weronika;Wisniewski，Marek;Roszek，Katarzyna
纳米材料大规模生产的快速增长，以及它们在消费品中的大量使用，逐渐增加了生物接触的潜在风险。纳米材料和纳米颗粒的一些独特性质促进了它们与生物分子的相互作用（纳米-生物相互作用）。嘌呤能信号系统是利用细胞外嘌呤核苷酸和核苷作为化学信使的最古老的进化和广泛的传递系统之一。然而，纳米材料与嘌呤能信号通路组分之间的相互作用尚未得到充分认识。鉴于新出现的数据，我们总结了目前的研究现状，并提出了纳米材料对不同类型细胞嘌呤能信号通路功能的影响的观点。所描述的纳米生物相互作用包括与嘌呤能受体或改变受体基因表达的直接相互作用、炎症过程的激活和细胞死亡的诱导。然而，精确的机制仍有待厘清。由于大多数归因于纳米材料的效应似乎诱导了无序的信号传导，这些相互作用不能被忽视。更好地了解纳米材料诱导的信号调节不仅对准确评估其毒性至关重要，而且对合成和设计新型、更安全的纳米材料也至关重要。
Rapid growth in the mass production of nanomaterials together with their abundant use in consumer products, progressively increases the potential risks of living organisms exposure. Some unique properties of nanomaterials and nanoparticles facilitate their interactions with biomolecules (nano-bio interactions). The purinergic signalling system is one of the oldest evolutionary and widespread transmitter system that utilizes extracellular purine nucleotides and nucleosides as chemical messengers. However, interactions between nanomaterials and components of purinergic signalling pathway have not been fully recognized so far. In view of the emerging data, we summarize the current state-of-art and present the perspectives of nanomaterials influence on the functions of purinergic signaling pathway in different types of cells. The described nano-bio interactions include inter alia direct interplay with purinergic receptors or altering receptor genes expression, activation of inflammatory processes, and induction of cell death. However, the precise mechanisms are yet still to be disentangled. Due to the fact that majority of the effects ascribed to nanomaterials seems to induce disordered signalling, these interactions cannot stay neglected. A better understanding of signalling modulations induced by nanomaterials is not only essential for the accurate assessment of their toxicity, but also for synthesis and design of novel, safer nanomaterials.