59.Age distribution and prevalence in different age groups of four myositis-specific autoantibodies, including anti-ARS, anti-MDA5, anti-Mi-2, and anti-TIF1γ antibodies
59.Age distribution and prevalence in different age groups of four myositis-specific autoantibodies, including anti-ARS, anti-MDA5, anti-Mi-2, and anti-TIF1γ antibodies
复制标题
59.抗ARS、抗MDA5、抗Mi-2及抗TIF1γ抗体等四种肌炎特异性自身抗体的年龄分布及不同年龄组的患病率
DOI：
10.1111/1346-8138.16772
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
M Fujimoto M
中科院分区：
文献类型：
--
作者：
Ueda-Hayakawa I;Tonomura K;Maekawa A;Kaneda E;Arase N;M Fujimoto M
随着肌炎特异性抗体 (MSA) 标准检测的普及，我们积累了人口统计信息，并分析了日本各地大型人群中肌炎特异性抗体 (MSA) 的患病率。这项回顾性、观察性、队列研究分析了日本各地 2014 年 1 月至 2020 年 4 月期间在 SRL Incorporation 接受血清 MSA 检测的 0-99 岁个体的记录。采用酶联免疫吸附测定法检测是否存在抗氨酰 tRNA 合成酶（抗 ARS）、抗 Mi-2、抗黑色素瘤分化相关基因 5（抗 MDA5）或抗转录中间因子 1-γ（抗 TIF1γ）（医学和生物实验室）。男性患者中检测到的抗 TIF1γ 抗体多于女性患者。相比之下，其他 MSA 患者中女性占主导地位。超过一半的抗 ARS 或抗 TIF1γ 抗体阳性患者年龄超过 60 岁，而抗 MDA5 或抗 Mi-2 抗体阳性患者大多年龄在 60 岁以下。抗MDA5抗体阳性患者年龄大多为40-59岁，而其他MSA组大多为60-79岁。抗 MDA5 抗体在 0-29 岁的年龄范围内最常见。抗 TIF1γ 抗体是 0-19 岁年龄范围内第二常见的自身抗体。抗ARS抗体是30岁以后最常检测到的自身抗体，并且随着年龄的增长，抗ARS的频率逐渐增加。在 30-79 岁年龄段，检测到的第二和第三大自身抗体分别是抗 MDA5 和抗 TIF1γ。我们在全国范围内对常规诊断环境中的 MSA 检测进行了为期 3 年以上的评估。本文提供了有关四种 MSA 类型与大量人群中性别和年龄分布之间关系的临床图像。
We accumulated the demographic information and analyzed the prevalence of myositis‐specific antibodies (MSAs) in a large cohort across Japan as standard testing for MSAs becomes more widely available. This retrospective, observational, cohort study analyzed the records of individuals aged 0–99 years who are tested for serum MSAs at SRL Incorporation from January 2014 to April 2020 across Japan. An enzyme‐linked immunosorbent assay testing was applied to determine the presence of anti‐aminoacyl tRNA synthetase (anti‐ARS), anti‐Mi‐2, anti‐melanoma differentiation‐associated gene 5 (anti‐MDA5), or anti‐transcriptional intermediary factor 1‐γ (anti‐TIF1γ) (Medical and Biological Laboratories). Anti‐TIF1γ antibody was detected more in male patients than female patients. In contrast, women were predominant in patients with other MSAs. More than half of the anti‐ARS or anti‐TIF1γ antibody‐positive patients were over 60 years old, although anti‐MDA5 or anti‐Mi‐2‐positive patients were mostly under <60 years old. Anti‐MDA5 antibody‐positive patients were mostly aged 40–59 years, while other MSA groups were mostly 60–79 years. Anti‐MDA5 antibody was detected most frequently in the age range of 0–29 years. Anti‐TIF1γ antibody was the second most commonly detected autoantibody in the age range of 0–19 years. Anti‐ARS antibody was the most frequently detected autoantibody after the age of 30 years, and the frequency of anti‐ARS gradually increased at more advanced ages. The second and third most detected autoantibodies were anti‐MDA5 and anti‐TIF1γ, respectively, in ages 30–79 years. We performed a nationwide >3‐year evaluation of MSA detection in a routine diagnostic setting. This paper provides clinical images concerning the relationship between four MSA types and the distribution of sex and age in a large population.