Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort
Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort
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DOI：
10.1038/s41372-021-01002-z
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发表时间：
2021-03-08
影响因子：
2.9
通讯作者：
EL-Khuffash, Afif
中科院分区：
文献类型：
--
作者：
Bussmann, Neidin;Smith, Aisling;EL-Khuffash, Afif
目的对动脉导管未闭（PDA）早期分流消除与慢性肺部疾病或死亡（CLD/ death）的关系进行事后评价。研究设计（婴儿0.05）。持续PDA超过第8天与CLD/死亡相关（aOR为6.5[1.7-25.5]）。结论与长期接触分流器的早产儿相比，早期排除PDA分流器可降低呼吸道发病率。
Objective A post hoc appraisal of the PDA RCT to assess the relationship between early patent ductus arteriosus (PDA) shunt elimination and chronic lung disease or death (CLD/Death). Study design Infants 0.05). A persistent PDA beyond Day 8 was associated with CLD/Death (aOR 6.5 [1.7-25.5]). Conclusions Early shunt elimination in preterm infants with a PDA may reduce respiratory morbidity when compared to infants with prolonged shunt exposure.