SUPPRESSION OF THE EGF-DEPENDENT INDUCTION OF C-MYC PROTOONCOGENE EXPRESSION BY TRANSFORMING GROWTH-FACTOR-BETA IN A HUMAN-BREAST CARCINOMA CELL-LINE
SUPPRESSION OF THE EGF-DEPENDENT INDUCTION OF C-MYC PROTOONCOGENE EXPRESSION BY TRANSFORMING GROWTH-FACTOR-BETA IN A HUMAN-BREAST CARCINOMA CELL-LINE
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DOI：
10.1016/0006-291x(87)91438-0
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发表时间：
1987-05-14
影响因子：
3.1
通讯作者：
HAMILTON, PD
中科院分区：
文献类型：
--
作者：
FERNANDEZPOL, JA;TALKAD, VD;HAMILTON, PD
表皮生长因子（EGF）和/或转化生长因子β治疗人乳腺癌MDA-468细胞后c-myc原癌基因表达的变化（tgf . β）已被研究。在EGF治疗后60分钟内检测到c-myc信使RNA的刺激。这种诱导持续了至少24小时，尽管程度较低。tgf . β的存在可抑制EGF诱导的早期和晚期c-myc mRNA水平的升高。TGF.beta。c-myc mRNA水平变化不大。tgf的作用。代表了这种激素在基因表达水平上的一种新作用。
Alterations in c-myc proto-oncogene expression after treatment of human mammary carcinoma MDA-468 cells with epidermal growth factor (EGF) and/or transforming growth factor .beta. (TGF.beta.) have been investigated. A stimulation of c-myc messenger RNA was detected within 60 min after treatment with EGF. This induction persisted for at least 24 hr, albeit to a lower extent. The early and late increase in c-myc mRNA levels induced by EGF were inhibited by the presence of TGF.beta.. TGF.beta. alone induced little change in c-myc mRNA levels. The effect of TGF.beta. represents a novel action of this hormone at the level of gene expression.