Zinc absorption during late pregnancy in rural southern Ethiopia
Zinc absorption during late pregnancy in rural southern Ethiopia
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DOI：
10.1093/ajcn/84.5.1102
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发表时间：
2006-11-01
影响因子：
7.1
通讯作者：
Krebs, Nancy F.
中科院分区：
文献类型：
--
作者：
Hambidge, K. Michael;Abebe, Yewelsew;Krebs, Nancy F.
背景资料：目前对妊娠晚期锌的吸收知之甚少，也没有关于总饮食中锌吸收的信息。目的：本研究的目的是测量埃塞俄比亚南部贫困农村妇女妊娠晚期每日锌吸收分数（FAZ）和估计吸收锌总量（TAZ）。设计：参与者（n = 17）是来自更大研究人群的方便样本。妊娠第三阶段由Bushulo健康中心产前外展计划根据宫高进行估计。FAZ测定与双同位素示踪剂的比例技术，使用测量尿富集与锌稳定同位素静脉和口服给药，作为一个外在的标签，与所有的膳食在1天。总膳食锌（TDZ）计算从称重饮食记录和埃塞俄比亚的食物成分表支持的锌和植酸盐分析的主要食物项目的个人餐。血浆锌和交换性锌池的大小也进行了估计。平均（+/- SD）FAZ为0.35 +/- 0.11，TDZ为6.0 +/- 3.2 mg/d，TAZ为2.1 +/- 1.0 mg/d，植酸盐摄入量为1033 +/- 843 mg/d，血浆锌为44.1 +/- 6.0 μ g/dL，交换性锌库为142 ± 39 mg.植酸与锌的摩尔比为17：1。结论：来自贫困农村的妇女，依赖于中等高植酸饮食，在妊娠晚期TDZ和血浆锌浓度较低。TAZ略高于预测值，但不符合生理要求。
Background: Little is yet known about zinc absorption in late pregnancy, and no information on absorption from the total diet is available.Objective: The objective was to measure the fractional absorption of zinc (FAZ) and to estimate the total quantity of absorbed zinc (TAZ) each day during the third trimester of pregnancy in poor rural southern Ethiopian women.Design: The participants (n = 17) were a convenience sample from a larger study population. The third stage of pregnancy was estimated from fundal height by the Bushulo Health Center prenatal outreach program. FAZ was determined with a dual-isotope tracer ratio technique that uses measurements of urine enrichment with zinc stable isotopes administered intravenously and orally, as an extrinsic label, with all meals in 1 d. Total dietary zinc (TDZ) was calculated from weighed diet records and Ethiopian food-composition tables supported by zinc and phytate analyses of major food items for individual meals. Plasma zinc and exchangeable zinc pool size were also estimated.Results: Mean (+/- SD) FAZ was 0.35 +/- 0.11, TDZ was 6.0 +/- 3.2 mg/d, TAZ was 2.1 +/- 1.0 mg/d, phytate intake was 1033 +/- 843 mg/d, plasma zinc was 44.1 +/- 6.0 mu g/dL, and the exchangeable zinc pool size was 142 +/- 39 mg. The molar ratio of phytate to zinc was 17:1.Conclusions: Women from a poor rural population who were dependent on a moderately high-phytate diet had low TDZ and low plasma zinc concentrations in the third trimester of pregnancy. TAZ was modestly higher than that predicted but did not meet physiologic requirements.