Therapeutic Strategies in the Development of Anti-viral Drugs and Vaccines Against SARS-CoV-2 Infection
Therapeutic Strategies in the Development of Anti-viral Drugs and Vaccines Against SARS-CoV-2 Infection
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DOI：
10.1007/s12035-020-02074-2
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发表时间：
2020-08-18
影响因子：
5.1
通讯作者：
Reddy, P. Hemachandra
中科院分区：
文献类型：
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作者：
Bhatti, Jasvinder Singh;Bhatti, Gurjit Kaur;Reddy, P. Hemachandra
目前，全球正面临由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的新型冠状病毒病2019（COVID-19）的大流行。这次爆发出乎意料地出现，对人类造成了潜在威胁，给个人和联邦政府带来了社会和经济负担。COVID-19最初始于中国武汉市，随后蔓延至全球，已被宣布为国际关注的突发公共卫生事件。确诊病例数的持续增加导致全球死亡率居高不下。越来越多的证据表明，死亡率在老年人和原有健康状况的人中占很大比例。然而，SARS-CoV-2感染人类的潜在发病机制仍然未知。失调/旺盛的免疫应答可能在很大程度上促成了SARS-CoV-2介导的病理学。然而，目前没有临床批准的药物/疫苗可以限制其发病机制。然而，目前有几种药物被证明可以为COVID-19患者提供一些治疗益处，包括可能在限制当前COVID-19大流行方面发挥重要作用的抗病毒药物。在这篇文章中，我们强调了COVID-19的药物治疗策略，并为开发针对人类SARS-CoV-2感染的疫苗或抗病毒药物分子提供了治疗靶点。
The whole world is currently facing a pandemic of an infectious disease known as novel coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) . This outbreak emerged unexpectedly and imposed a potential threat to humans, associated with the social and economic burden on the individual and federal governments. COVID-19, which initially started in Wuhan City of China and then spread to the whole world, has been declared a Public Health Emergency of International Concern. The continuous increase in the number of confirmed cases leads to high mortality across the world. Growing evidence indicates that the mortality rate is very predominant in elderly people and those with preexisting health conditions. However, the potential pathogenesis of SARS-CoV-2 infection in humans is still unknown. The dysregulated/exuberant immune response may have substantially contributed to the SARS-CoV-2-mediated pathology. Nevertheless, there is no clinically approved drug/vaccine currently available that can restrict its pathogenesis. However, several drugs are currently shown to provide some therapeutic benefits for COVID-19 patients, including antiviral drugs that might have a significant role in restricting the current pandemic of COVID-19. In this article, we highlighted the pharmacological treatment strategies for COVID-19 and purposed the therapeutic targets for the development of vaccines or anti-viral drug molecules against SARS-CoV-2 infection in humans.