Relations of blood pressure to angiotensinogen gene T174M polymorphism and alcohol intake.
Relations of blood pressure to angiotensinogen gene T174M polymorphism and alcohol intake.
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DOI：
10.2114/jpa.22.187
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发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Sumiya, Yu
中科院分区：
文献类型：
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作者：
Takashima, Yutaka;Kokaze, Akatsuki;Sumiya, Yu
目的：探讨日本男性工人饮酒与血管紧张素原基因第174密码子（T174M）多态性对血压的影响。根据2000年对185名日本男性工人进行的健康检查、营养调查和T174M基因型分析的数据，比较了两种T174M基因型类别交叉的四个亚组之间正常高值血压（HNBP）和高血压的患病率（“TT”型和“TM或MM”型）和两种酒精摄入量类别（每天少于13.7 g和每天13.7 g或更多）。此外，对于其中1998年血压正常的95名受试者，在2000年发展为HNBP或高血压的风险在四个亚组中进行了比较。结果显示，2000年经年龄、体重指数、吸烟习惯和钠摄入量调整后的HNBP患病率显著高于2001年，（p=0.03）“TM或MM”型更大（57.9%）高于TT型（24.9%）在每日酒精摄入量≥ 13.7 g的受试者中，而在每日饮酒量低于13.7 g的人群中，这两种基因型的这一参数无差异（分别为18.2%和18.3%）。在2000年，在四个亚组中，每日饮酒量为13.7 g或更多的“TM或MM”型患者发展为HNBP的风险也最大，尽管四个亚组之间没有显著差异。高血压的患病率或高血压的发展风险在四个亚组之间没有显著差异。因此，在血管紧张素原基因T174M多态性的M等位基因携带者中，饮酒可能与HNBP特异性相关。
To clarify the interactive effects of alcohol intake and angiotensinogen gene codon 174 (T174M) polymorphisms on blood pressure in Japanese male workers. On the basis of data from health examinations, nutrition survey and T174M genotype analysis conducted for 185 Japanese male workers at 2000, the prevalence of high-normal blood pressure (HNBP) and hypertension were compared between the four subgroups crossed by two T174M genotype categories ('TT' type, and 'TM or MM' type) and two alcohol intake categories (less than 13.7 g per day, and 13.7 g or more per day). Furthermore, for 95 subjects who had been normotensive at 1998 among them, risk of development into HNBP or hypertension at 2000 were compared across the four subgroups. The findings showed that the HNBP prevalence adjusted for age, body mass index, smoking habits and sodium intake in 2000 was significantly (p=0.03) greater in 'TM or MM' type (57.9%) than in 'TT' type (24.9%) in subjects with 13.7 g or more of daily alcohol intake, whereas no difference in this parameter was found between the two genotypes in those with less than 13.7 g of daily alcohol intake (18.2% and 18.3%, respectively). The risk for development into HNBP at 2000 was also greatest in 'TM or MM' type with 13.7 g or more of daily alcohol intake among the four subgroups, although there were not significant differences between the four subgroups. The prevalence of hypertension or development risk for hypertension did not significantly differ between the four subgroups. Therefore, it can be seen that alcohol drinking might be specifically associated with the HNBP in M allele carriers of angiotensinogen gene T174M polymorphism.