Multifunctional Nanoparticles for Combined Doxorubicin and Photothermal Treatments
Multifunctional Nanoparticles for Combined Doxorubicin and Photothermal Treatments
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DOI：
10.1021/nn900215k
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发表时间：
2009-10-01
期刊：
影响因子：
17.1
通讯作者：
Yoo, Kyung-Hwa
中科院分区：
文献类型：
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作者：
Park, Huiyul;Yang, Jaemoon;Yoo, Kyung-Hwa
为了促进多柔比星和光热联合处理，我们通过在多柔比星负载的PLGA NPs上沉积所有薄膜，开发了负载多柔比星的聚（乳酸-羟基乙酸）-金半壳纳米粒子（dox负载PLGA- au H-S NPs）。当PLGA NPs生物降解时，DOX被释放，并且由于负载DOX的PLGA H-S NPs的近红外共振，在近红外（NIR）照射下局部产生热量。与单纯化疗或光热治疗相比，联合治疗具有协同作用，治疗效果更高，治疗时间更短。由于我们的NPs选择性地将热量和药物传递到致瘤区域，它们可能以最小的副作用提高治疗效果。
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing All films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.