Gut microbiota: a key regulator of ageing-associated atrial fibrillation?
Gut microbiota: a key regulator of ageing-associated atrial fibrillation?
复制标题
肠道微生物群：衰老相关心房颤动的关键调节因子？
DOI：
10.1093/cvr/cvab346
复制
发表时间：
2022
影响因子：
10.8
通讯作者：
Wehrens,XanderHT
中科院分区：
文献类型：
--
作者：
Li,Na;Durgan,DavidJ;Wehrens,XanderHT
心房颤动（AF）是老年患者最常见的疾病之一，其患病率随着年龄的增长而增加。在80岁以上的人群中，大约有10%的人患有房颤。老年人房颤的高发是由于老化的心脏发生退行性改变，以及冠状动脉疾病、慢性肾病、心力衰竭和高血压等合并症的增加。炎症已被认为是房颤发生的病理生理机制。此外，新出现的证据表明，肠道微生物组成的改变可能有助于房颤的发展。
Atrial fibrillation (AF) is one of the most common diseases in elderly patients, and its prevalence increases with age. Approximately 10% of people over 80 years of age suffer from AF. The high prevalence of AF in the elderly has been attributed to degenerative changes in the ageing heart and the rise in comorbid conditions such as coronary artery disease, chronic kidney disease, heart failure, and hypertension. 1 Inflammation has been suggested as a pathophysiological mechanism underlying AF development. 2 In addition, emerging evidence suggests that alterations in the gut microbial composition might contribute to AF development.