The generalized sib pair IBD distribution: its use in the detection of linkage
The generalized sib pair IBD distribution: its use in the detection of linkage
复制标题
广义同胞对 IBD 分布：其在连锁检测中的应用
DOI：
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发表时间：
1978
影响因子：
1.9
通讯作者：
Theodore Reich
中科院分区：
文献类型：
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作者：
Brian K. Suarez;J. P. Rice;Theodore Reich
对于由具有任意基因频率和外显性载体的连锁性状基因座决定的疾病，既不给出一个，也不给出一个或两个都受影响的同胞，已推导出标记基因座上IBD分数分布的一般表达式。结果表明，IBD得分的分布仅取决于疾病的加性和显性方差以及疾病的总体流行率。
General expressions for the distribution of identity by descent (IBD) scores at a marker locus have been derived given neither, one or both sibs affected with a disorder determined by a linked trait locus with arbitrary gene frequency and penetrance vector. It is shown that the distribution of IBD scores depends only on the additive and dominance variances and the population prevalence of the disorder.