Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria
Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria
复制标题
DOI：
10.1111/j.1365-2125.2011.04010.x
复制
发表时间：
2011-09-01
影响因子：
3.4
通讯作者：
Chan, Ding-Cheng (Derrick)
中科院分区：
文献类型：
--
作者：
Chang, Chirn-Bin;Chen, Jen-Hau;Chan, Ding-Cheng (Derrick)
我们的目的是比较六种不同的潜在不适当药物（PIM）标准在老年门诊多药患者中的实用性。方法分析台湾老年人用药安全评价临床（MSRC-Taiwan）研究的基线数据。根据美国、加拿大、法国、挪威、爱尔兰和泰国制定的标准，确定了pim的患病率和相关因素。报告了被视为与毒品有关的问题的pim百分比和解决问题的比率。结果在193名参与者中，PIM患病率为24% ~ 73%。标准的应用表明，大量的慢性药物是至少有一种PIM的常见危险因素。在回顾的1713种药物中，5.6-14.8%被认为是pim。只有30-40%的已确定的pim被MSRC团队专家报告为与药物有关的问题。声明数量较多和当地市场/机构药物可得性百分比较高的标准往往检出更多的pim。结论不同标准的PIM患病率差异显著。当当地市场的药物供应有限时，在应用其他地区制定的PIM标准时应谨慎行事。
AIMOur aim was to compare the practicability of six different potentially inappropriate medication (PIM) criteria in geriatric outpatients with polypharmacy.METHODSWe analysed baseline data from the Medication Safety Review Clinic in Taiwanese Elders (MSRC-Taiwan) study. The prevalence and correlates of PIMs were determined on the basis of criteria developed in the USA, Canada, France, Norway, Ireland and Thailand. The percentage of PIMs considered as drug-related problems and the problem-solving rate are reported.RESULTSIn the 193 participants, the prevalence of PIM varied from 24 to 73%. Application of the criteria revealed that a high number of chronic medications was a common risk factor for having at least one PIM. Of the 1713 medications reviewed, 5.6-14.8% were considered PIMs. Only 30-40% of the identified PIMs were reported as drug-related problems by the MSRC team experts. Criteria with a higher number of statements and a higher percentage of local market/institution drug availability tended to detect more PIMs.CONCLUSIONSThe prevalence of PIM varied significantly when different criteria were applied. Caution should be exercised in applying PIM criteria developed in other regions when medication availability in the local market is limited.