P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury
P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury
复制标题
DOI：
10.1016/s0006-8993(99)01637-6
复制
发表时间：
1999-07-24
期刊：
影响因子：
2.9
通讯作者：
Frenette, PS
中科院分区：
文献类型：
--
作者：
Soriano, SG;Wang, YMF;Frenette, PS
我们检查了局灶性脑缺血再灌注（I/R）组织损伤后P-和E-选择素缺陷小鼠（-/-）及其非转基因同窝小鼠（+/+）的脑切片。缺血3 h和再灌注21 h后的梗死体积无差异。这些数据表明，选择素的非依赖性机制介导组织损伤后，一段时间的短暂局灶性缺血。(C)1999 Elsevier Science B. V.保留所有权利。
We examined brain sections from P- and E-selectin-deficient mice (-/-)and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia. (C) 1999 Elsevier Science B.V. All rights reserved.