Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
Oligoclonal IgG bands in Japanese patients with multiple sclerosis. A comparative study between isoelectric focusing with IgG immunofixation and high-resolution agarose gel electrophoresis
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DOI：
10.1016/j.jneuroim.2004.09.011
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Itoyama, Y
中科院分区：
文献类型：
--
作者：
Nakashima, I;Fujihara, K;Itoyama, Y
与西方多发性硬化症(MS)相比，日本多发性硬化症(MS)具有低频率的寡克隆抗体条带(OB)。我们比较了59例临床确诊的多发性硬化症(MS)患者的等电聚焦(IEF)和琼脂糖凝胶电泳法(AGE)中的OB频率，其中39例为传统型MS(CMS)，20例为视脊髓型MS(OSMS)。IEF-OB占MS总数的54%，而AGE-OB仅占17%。当排除OSM时，IEF的频率增加到77%，而随着年龄的增加，频率保持在23%。我们的研究有力地表明，IEF对于检测日本MS患者的OB是非常有效的。(C)2004爱思唯尔B.V.保留所有权利。
A low prevalence of oligoclonal IgG bands (OB) has been reported as a unique feature of Japanese multiple sclerosis (MS) as compared with Western MS. We compared the frequency of OB between isoelectric focusing (IEF) and agarose gel electrophoresis (AGE) in 59 Japanese patients with clinically definite MS [39 with conventional form of MS (CMS) and 20 with optic-spinal form of MS (OSMS)]. The frequency of IEF-OB in total MS was 54%, whereas that of AGE-OB was only 17%. When OSMS was excluded, the frequency increased to 77% by IEF, whereas it remained 23% by AGE. Our study strongly suggests that IEF is highly effective for detecting OB in Japanese MS patients. (C) 2004 Elsevier B.V. All rights reserved.