An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
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DOI：
10.1016/s1053-8119(03)00169-1
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发表时间：
2003-07-01
期刊：
影响因子：
5.7
通讯作者：
Burdette, JH
中科院分区：
文献类型：
--
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
功能性磁共振成像（fMRI）数据的分析和解读传统上是基于在整个成像脑体积的阈值统计图谱上识别显著区域。这种分析形式可被比作“搜索式研究”。随着我们对不同脑区的结构 - 功能关系了解得更多，就需要用于先验假设检验的工具。这些工具必须能够以最小的工作量持续生成用于先验假设检验的感兴趣区域模板。当前用于生成先验假设检验所需的感兴趣区域模板的工具可能很耗时，并且通常是特定于实验室的。在本文中，我们展示了一种使用基于自动图谱的模板技术进行假设驱动数据分析的方法。我们提供了一种强大的方法，即使用基于脑叶解剖、皮质和皮质下解剖以及布罗德曼区自动生成的模板来探究fMRI数据。基于Talairach Daemon在MNI空间中生成了半球、脑叶、解剖标记、组织类型和布罗德曼区图谱。此外，我们将这些多卷图谱与广泛使用的fMRI软件包SPM99相连接，并使用代表性的fMRI数据演示了图谱工具的使用。该工具代表了fMRI数据分析在测试更复杂空间假设方面的必要进展。（C）2003年爱思唯尔科学（美国）。保留所有权利。
Analysis and interpretation of functional MRI (fMRI) data have traditionally been based on identifying areas of significance on a thresholded statistical map of the entire imaged brain volume. This form of analysis can be likened to a "fishing expedition." As we become more knowledgeable about the structure-function relationships of different brain regions, tools for a priori hypothesis testing are needed. These tools must be able to generate region of interest masks for a priori hypothesis testing consistently and with minimal effort. Current tools that generate region of interest masks required for a priori hypothesis testing can be time-consuming and are often laboratory specific. In this paper we demonstrate a method of hypothesis-driven data analysis using an automated atlas-based masking technique. We provide a powerful method of probing fMRI data using automatically generated masks based on lobar anatomy, cortical and subcortical anatomy, and Brodmann areas. Hemisphere, lobar, anatomic label, tissue type, and Brodmann area atlases were generated in MNI space based on the Talairach Daemon. Additionally, we interfaced these multivolume atlases to a widely used fMRI software package, SPM99, and demonstrate the use of the atlas tool with representative fMRI data. This tool represents a necessary evolution in fMRI data analysis for testing of more spatially complex hypotheses. (C) 2003 Elsevier Science (USA). All rights reserved.