Increased sympathetic nervous activity in patients with nontraumatic subarachnoid hemorrhage
Increased sympathetic nervous activity in patients with nontraumatic subarachnoid hemorrhage
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DOI：
10.1161/01.str.31.4.901
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发表时间：
2000-04-01
期刊：
影响因子：
8.3
通讯作者：
Friberg, P
中科院分区：
文献类型：
--
作者：
Naredi, S;Lambert, G;Friberg, P
背景和目的：交感神经系统的激活，导致循环中儿茶酚胺的升高，与蛛网膜下腔出血后脑血管痉挛和心脏畸变的发生有关。到目前为止，交感神经测试仅依赖于间接方法。方法我们使用同位素稀释技术来估计18名蛛网膜下腔患者交感肾上腺激活的幅度和时间过程。结果与2个不同的对照组相比，蛛网膜下腔出血患者在损伤后48小时内全身去甲肾上腺素溢出到血浆中的量增加约3倍（3.2+/-0.3和4.2+/-0.7对比10.2+/-1.4 nmol/L; P
Background and Purpose-Activation of the sympathetic nervous system, which leads to elevation of circulating catecholamines, is implicated in the genesis of cerebral vasospasm and cardiac aberrations after subarachnoid hemorrhage. To this juncture, sympathetic nervous testing has relied on indirect methods only.Methods We used an isotope dilution technique to estimate the magnitude and time course of sympathoadrenal activation in 18 subarachnoid patients.Results-Compared with 2 different control groups, the patients with subarachnoid hemorrhage exhibited an approximately 3-fold increase in total-body norepinephrine spillover into plasma within 48 hours after insult (3.2+/-0.3 and 4.2+/-0.7 versus 10.2+/-1.4 nmol/L; P