Sensory distinction between H-2b and H-2bm1 mutant mice.
Sensory distinction between H-2b and H-2bm1 mutant mice.
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H-2b 和 H-2bm1 突变小鼠之间的感觉区别。
DOI：
10.1073/pnas.80.18.5685
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发表时间：
1983
影响因子：
11.1
通讯作者：
Boyse,EA
中科院分区：
文献类型：
--
作者：
Yamazaki,K;Beauchamp,GK;Egorov,IK;Bard,J;Thomas,L;Boyse,EA
17号染色体H-2：QA：TLA区域的遗传多态与体臭表型的结构性变异有关，体味表型允许小鼠之间的个体嗅觉识别。为了确定H-2：QA：TLA复合体中的已知基因是否与气味表型的构成有关，我们测试了小鼠对B6/by(H-2b)菌株和同源B6.C-H-2bm1菌株之间的区别的能力，这两种菌株通过H-2K基因的突变而在遗传上有所不同。与以前关于H-2：Qa：Tla表型感觉辨别的研究一样，小鼠在Y迷宫中接受奖励训练，以辨别尿样的气味，并通过将训练无偿转移到来自基因等同的尿液供体小鼠的编码尿样上，证实了B6/By和B6的成功区分。通过训练转移到相应杂交F2世代的H-2b和H-2bm1纯合子分离株，证明了气味表型与H-2b和H-2bm1的共分离。虽然不排除H-2b和H-2bm1小鼠气味表型的差异与H-2b和H-2bm1产物的结构直接相关，但与H-2相关的气味表型也同样可能是由H-2基因变异对代谢途径的直接或间接影响而产生的。
Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested for their ability to sense a difference between the B6/By (H-2b) and congeneic B6.C-H-2bm1 strains, which differ genetically by mutation of the H-2K gene. As in previous studies of the sensory discrimination of H-2:Qa:Tla phenotypes, mice were trained by reward in a Y maze to distinguish the odors of urine samples, and the successful distinctions of B6/By from B6.C-H-2bm1 were confirmed by transfer of training, without reward, to coded samples of urine from genetically equivalent urine donor mice which the trained mice had not previously encountered. Cosegregation of odor phenotype with H-2b and H-2bm1 was demonstrated by transfer of training to typed H-2b and H-2bm1 homozygous segregants of F2 generations of appropriate crosses. Although it is not excluded that the differences in odor phenotype which distinguish H-2b and H-2bm1 mice are directly related to the structure of the H-2b and H-2bm1 products, it is equally possible that H-2-related odor phenotypes arise from effects of H-2 genetic variation on metabolic pathways either directly, or indirectly through developmental polymorphism.