LASSA VIRUS HEPATITIS - A STUDY OF FATAL LASSA FEVER IN HUMANS
LASSA VIRUS HEPATITIS - A STUDY OF FATAL LASSA FEVER IN HUMANS
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DOI：
10.4269/ajtmh.1986.35.401
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发表时间：
1986-03-01
影响因子：
3.3
通讯作者：
JOHNSON, KM
中科院分区：
文献类型：
--
作者：
MCCORMICK, JB;WALKER, DH;JOHNSON, KM
为了探讨以前观察到的致命性拉沙热最重要的病理变化是肝脏的意义，我们研究了19例致命性拉沙热患者的死后肝活检。我们观察到一个有力的巨噬细胞对细胞损伤的反应，但我们没有发现淋巴细胞浸润的证据在感染的肝组织。通过对肝细胞损伤的半定量评估，我们发现在我们的致死性病例中，拉沙病毒性肝炎的严重程度和进展范围很广。为了描述的目的，我们将疾病发生分为三个阶段：活动性肝细胞损伤（< 20%坏死），持续损伤和早期恢复，以及代表肝脏恢复的有丝分裂活动。我们的结论是，肝脏经过细胞损伤，坏死和再生，任何或所有可能存在于死亡。在任何情况下，肝损害的程度都不足以导致肝功能衰竭，所有三个阶段都在我们的病例中得到了体现。我们的结论是，拉沙热肝炎在人类中不是主要的死亡原因。
In order to explore the significance of a previous observation that the most important pathologic changes in fatal Lassa fever are hepatic, we have studied postmortem liver biopsies from 19 patients with fatal Lassa fever. We observed a vigorous macrophage response to cellular damage, but we found no evidence of lymphocyte infiltration in infected hepatic tissues. Using semi-quantitative estimates of liver cell damage, we found a wide range in the severity and progression of Lassa virus hepatitis in our fatal cases. We have classified for descriptive purposes three general nosopoietic phases: active hepatocellular injury (< 20% necrosis), continued damage and early recovery, and mitotic activity representing hepatic recovery. We conclude that the liver goes through cellular injury, necrosis and regeneration and any or all may be present at death. In no instance was the degree of hepatic damage sufficient to implicate hepatic failure, and all three phases were represented among our cases. We conclude that the hepatitis of Lassa fever in humans is not the primary cause of death.