Decreased muscle strength and quality in older adults with type 2 diabetes - The health, aging, and body composition study
Decreased muscle strength and quality in older adults with type 2 diabetes - The health, aging, and body composition study
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DOI：
10.2337/db05-1183
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发表时间：
2006-06-01
期刊：
影响因子：
7.7
通讯作者：
Newman, Anne B.
中科院分区：
文献类型：
--
作者：
Park, Seok Won;Goodpaster, Bret H.;Newman, Anne B.
足够的骨骼肌力量对于身体功能至关重要，而低肌肉力量是身体限制的预测因素。患有糖尿病的老年人身体残疾的风险增加两到三倍。然而，从未在基于人群的研究中研究过肌肉力量与糖尿病的关系。我们在健康、衰老和身体成分研究中评估了 485 名患有糖尿病的老年人和 2,133 名没有糖尿病的老年人的握力和膝伸肌力量和肌肉质量。患有糖尿病的老年人比没有糖尿病的老年人有更大的手臂和腿部肌肉质量，因为他们的体型更大。尽管如此，男性糖尿病患者的肌肉力量较低，而女性糖尿病患者的肌肉力量并不高于相应的同行。肌肉质量（定义为每单位区域肌肉质量的肌肉力量）在男性和女性糖尿病患者中的上肢和下肢均显着低于未糖尿病患者。此外，较长的糖尿病病程（>= 6 年）和血糖控制不佳（HbA(1c) > 8.0%）与较差的肌肉质量相关。总之，糖尿病与骨骼肌强度和质量较低有关。这些特征可能会导致患有糖尿病的老年人出现身体残疾。
Adequate skeletal muscle strength is essential for physical functioning and low muscle strength is a predictor of physical limitations. Older adults with diabetes have a two-to threefold increased risk of physical disability. However, muscle strength has never been investigated with regard to diabetes in a population-based study. We evaluated grip and knee extensor strength and muscle mass in 485 older adults with diabetes and 2,133 without diabetes in the Health, Aging, and Body Composition study. Older adults with diabetes had greater arm and leg muscle mass than those without diabetes because they were bigger in body size. Despite this, muscle strength was lower in men with diabetes and not higher in women with diabetes than corresponding counterparts. Muscle quality, defined as muscle strength per unit regional muscle mass, was significantly lower in men and women with diabetes than those without diabetes in both upper and lower extremities. Furthermore, longer duration of diabetes ( >= 6 years) and poor glycemic control (HbA(1c) > 8.0%) were associated with even poorer muscle quality. In conclusion, diabetes is associated with lower skeletal muscle strength and quality. These characteristics may contribute to the development of physical disability in older adults with diabetes.