Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults
Prefrontal cortex volume reductions and tic inhibition are unrelated in uncomplicated GTS adults
复制标题
DOI：
10.1016/j.jpsychores.2013.10.014
复制
发表时间：
2014-01-01
影响因子：
4.7
通讯作者：
Muenchau, Alexander
中科院分区：
文献类型：
--
作者：
Ganos, Christos;Kuehn, Simone;Muenchau, Alexander
背景：吉尔·德拉抽动秽语综合症（GTS）的抽动是重复的模式化运动，类似于自发运动行为，但无法自主控制。之前的研究使用基于体素的形态测量（VBM）假设了 GTS 成人前额叶皮层结构改变与抽动严重程度之间的关系，但未能证明存在显着关联。前额皮质结构和抽动抑制之间的关系尚未被研究。方法：在这里，我们使用 VBM 检查 14 名没有相关合并症的 GTS 成年人和 15 名健康对照。我们将 GTS 的结构改变与抽动严重程度和抽动控制的临床测量相关联。结果：与健康对照相比，患者右额下回和左额极的灰质体积减少。这些变化与抽动严重程度和抽动抑制无关。结论：GTS 成人前额叶灰质体积减少与抽动现象学的状态测量无关。 (C) 2013 Elsevier Inc. 保留所有权利。
Background: Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.Methods: Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.Results: Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.Conclusion: Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology. (C) 2013 Elsevier Inc. All rights reserved.