Quantification of tympanic membrane elasticity parameters from in situ point indentation measurements: Validation and preliminary study
Quantification of tympanic membrane elasticity parameters from in situ point indentation measurements: Validation and preliminary study
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DOI：
10.1016/j.heares.2009.09.007
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发表时间：
2010-05-01
期刊：
影响因子：
2.8
通讯作者：
Dirckx, Joris J. J.
中科院分区：
文献类型：
--
作者：
Aernouts, Jef;Soons, Joris A. M.;Dirckx, Joris J. J.
正确定量地描述鼓膜弹性是实现中耳力学真实建模的重要输入。过去，人们曾多次尝试通过剪断条的拉伸实验来确定鼓膜的弹性。这种实验中的应变和应力可能远远超出生理相关范围，并且弹性参数只是部分确定。我们开发了一个装置来确定鼓膜弹性原位，使用点微压痕和云纹轮廓术的组合。在鼓膜乳胶模体模型上进行了测试，结果表明所测得的参数是正确的。通过压痕实验的有限元模拟和参数优化程序对这些参数进行了计算。当仪器用于兔鼓膜时，云纹轮廓术显示，在小的压痕过程中，胸柄没有可测量的位移。这一结果极大地简化了边界条件，因为我们可以认为环空和柄柄都是固定的，而不必依赖固定干预。该技术使我们能够原位测定鼓膜的线弹性材料参数。通过这种方式，我们的方法考虑到膜的复杂几何形状，并在生理上相关的应变范围内获得参数。(C) 2009 Elsevier B.V.版权所有
Correct quantitative parameters to describe tympanic membrane elasticity are an important input for realistic modeling of middle ear mechanics. In the past, several attempts have been made to determine tympanic membrane elasticity from tensile experiments on cut-out strips. The strains and stresses in such experiments may be far out of the physiologically relevant range and the elasticity parameters are only partially determined.We developed a setup to determine tympanic membrane elasticity in situ, using a combination of point micro-indentation and Moire profilometry. The measuring method was tested on latex phantom models of the tympanic membrane, and our results show that the correct parameters can be determined. These parameters were calculated by finite element simulation of the indentation experiment and parameter optimization routines.When the apparatus was used for rabbit tympanic membranes, Moire profilometry showed that there is no measurable displacement of the manubrium during the small indentations. This result greatly simplifies boundary conditions, as we may regard both the annulus and the manubrium as fixed without having to rely on fixation interventions. The technique allows us to determine linear elastic material parameters of a tympanic membrane in situ. In this way our method takes into account the complex geometry of the membrane, and parameters are obtained in a physiologically relevant range of strain. (C) 2009 Elsevier B.V. All rights reserved.