The role of TREX in gene expression and disease.
The role of TREX in gene expression and disease.
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DOI：
10.1042/bcj20160010
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发表时间：
2016-10-01
期刊：
影响因子：
--
通讯作者：
Wilson SA
中科院分区：
文献类型：
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作者：
Heath CG;Viphakone N;Wilson SA
转录与输出(TREX)是一种保守的多亚基复合体，在整个生命过程中对胚胎发生、器官发生和细胞分化都是必不可少的。通过将转录、mRNA加工和输出联系在一起，它在基因表达途径中发挥着生理上的重要作用。此外，该复合体通过确保最佳的基因表达来防止DNA损伤和调节细胞周期。随着TREX在病毒感染、肌萎缩侧索硬化症和癌症中的活性程度的出现，对TREX功能的更多了解的必要性变得明显。对该复合体的组成、功能和相互作用的完整阐明将为理解各种疾病的分子基础提供框架。这篇综述详细介绍了TREX的已知组成，它是如何调节的，以及它的细胞功能，重点是哺乳动物系统。
TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In addition, this complex prevents DNA damage and regulates the cell cycle by ensuring optimal gene expression. As the extent of TREX activity in viral infections, amyotrophic lateral sclerosis and cancer emerges, the need for a greater understanding of TREX function becomes evident. A complete elucidation of the composition, function and interactions of the complex will provide the framework for understanding the molecular basis for a variety of diseases. This review details the known composition of TREX, how it is regulated and its cellular functions with an emphasis on mammalian systems.