Promoter mutations of an essential gene for pollen development result in disease resistance in rice
Promoter mutations of an essential gene for pollen development result in disease resistance in rice
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DOI：
10.1101/gad.1416306
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发表时间：
2006-05-15
影响因子：
10.5
通讯作者：
Wang, Shiping
中科院分区：
文献类型：
--
作者：
Chu, Zhaohui;Yuan, Meng;Wang, Shiping
抗病性和性生殖发育通常被认为是由不同基因组调控的独立生物过程。在这里，我们表明，xa 13，一个隐性等位基因赋予对白叶枯病，世界上最具破坏性的水稻疾病之一，抗病性和花粉发育中起着关键作用。显性等位基因Xa 13是细菌生长和花粉发育所必需的。Xa 13的启动子突变导致宿主-病原体相互作用期间表达下调，导致赋予种族特异性抗性的完全隐性的Xa 13。隐性等位基因xa 13代表了一种新型的植物抗病性。
Disease resistance and sexual reproductive development are generally considered as separate biological processes, regulated by different sets of genes. Here we show that xa13, a recessive allele conferring disease resistance against bacterial blight, one of the most devastating rice diseases worldwide, plays a key role in both disease resistance and pollen development. The dominant allele, Xa13, is required for both bacterial growth and pollen development. Promoter mutations in Xa13 cause down-regulation of expression during host-pathogen interaction, resulting in the fully recessive xa13 that confers race-specific resistance. The recessive xa13 allele represents a new type of plant disease resistance.