Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins - Implication in initiation of atrial fibrillation
Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins - Implication in initiation of atrial fibrillation
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DOI：
10.1161/hc4801.099736
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发表时间：
2001-12-04
期刊：
影响因子：
37.8
通讯作者：
Lin, CI
中科院分区：
文献类型：
--
作者：
Chen, YJ;Chen, SA;Lin, CI
背景-肺静脉（PV）是阵发性心房颤动的重要来源。长期快速心房起搏（RAP）会改变心房电生理学并促进心房颤动的维持。目前尚不清楚 RAP 是否会改变 PV 的致心律失常活性。本研究的目的是从对照犬和 RAP 犬中分离单个 PV 心肌细胞并评估其电生理学。特征。方法和结果-通过使用全细胞钳技术，研究了来自对照和长期（6至8周）RAP（780 bpm）狗的PV心肌细胞的动作电位和离子电流。 PV 解离产生杆状单心肌细胞，不具有起搏器活性（n=91，60%）或具有起搏器活性（n=60，40%）。与对照组相比，RAP狗PV心肌细胞的搏动率更快（0.86 +/-0.28 vs 0.45 +/-0.07 Hz，P
Background-Pulmonary veins (PVs) are important sources of paroxysmal atrial fibrillation. Long-term rapid atrial pacing (RAP) changes atrial electrophysiology and facilitates the maintenance of atrial fibrillation. It is not clear whether RAP alters the arrhythmogenic activity of PVs. The purpose of this study was to isolate single PV cardiomyocytes from control and RAP dogs and evaluate their electrophysiological. characteristics.Methods and Results-The action potential and ionic currents were investigated in PV cardiomyocytes from control and long-term (6 to 8 weeks) RAP (780 bpm) dogs by use of the whole-cell clamp technique. Dissociation of PVs yielded rod-shaped single cardiomyocytes without (n=91, 60%) or with (n=60, 40%) pacemaker activity. Compared with the control group, the RAP dog PV cardiomyocytes had faster beating rates (0.86 +/-0.28 versus 0.45 +/-0.07 Hz, P