Age-dependence of hepatic dimethylnitrosamine-demethylase activity in the rat.
Age-dependence of hepatic dimethylnitrosamine-demethylase activity in the rat.
复制标题
大鼠肝二甲基亚硝胺去甲基酶活性的年龄依赖性。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
M. Argus
中科院分区：
文献类型：
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作者：
D. L. Davies;G. M. Bryant;J. Arcos;M. Argus
在大鼠肝脏中测定了激活致癌物二甲基亚硝胺(DMN)的混合功能氧化酶随动物年龄的变化。DMN-脱甲基酶活性最初显著增加，在第29天达到最大值，然后大幅下降到第59天；此后，酶活性基本保持稳定，至少到第110天。用3-甲基胆蒽处理后，这种酶的活性显著降低，但并不影响年龄依赖曲线的总体形状。结果表明，断奶到性成熟之间的大鼠比新生儿或成年动物更容易受到脉冲剂量DMN的致癌作用的影响。
The mixed-function oxidase which activates the carcinogen dimethylnitrosamine (DMN) was determined in the rat liver as a function of animal age. DMN-demethylase activity increased considerably at first to reach a maximum on day 29, and then substantially decreased to day 59; thereafter, enzyme activity remained essentially stable up to at least day 110. Pretreatment with 3-methylcholanthrene, which caused a pronounced decrease in this enzyme activity, did not affect the general shape of the age-dependence curve. The results suggest that rats between weaning and sexual maturity are more susceptible to the carcinogenic effects of pulse doses of DMN than are neonates or adult animals.