Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory‐activated airway vagal preganglionic neurons
Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory‐activated airway vagal preganglionic neurons
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DOI：
10.1113/expphysiol.2012.066589
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发表时间：
2013-01
影响因子：
2.7
通讯作者：
Xujiao Zhou;Yonghua Chen;D. Ge;W. Yuan;Jijiang Wang
中科院分区：
文献类型：
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作者：
Xujiao Zhou;Yonghua Chen;D. Ge;W. Yuan;Jijiang Wang
•本研究的中心问题是什么？迷走神经节前神经元（AVPNs）为神经节后神经元提供必要的兴奋驱动，神经节后神经元在生理上主导着气道的神经控制，在一些常见气道疾病的发病机制中起重要作用。avpn表达多种尼古丁乙酰胆碱受体亚基，但外源尼古丁或内源乙酰胆碱的影响尚不清楚。•主要发现是什么及其重要性？尼古丁和内源性乙酰胆碱都在吸气激活的AVPNs中引起突触后兴奋电流，并增强兴奋性和抑制性突触输入。尼古丁对吸入激活的AVPNs的总体作用是兴奋性的。烟碱对吸入激活AVPNs的影响是突触前通过α4β2型nachr的激活介导的，突触后通过α7和α4β2型nachr的激活介导。
• What is the central question of this study? Airway vagal preganglionic neurons (AVPNs) supply the essential excitatory drive to the postganglionic neurons, which dominate the neural control of the airway physiologically and play critical roles in the pathogenesis of some common airway disorders. AVPNs express multiple subunits of nicotinic acetylcholine receptors (nAChRs), but the influences of exogenous nicotine or endogenous acetylcholine are unknown. • What is the main finding and its importance? Nicotine and endogenous acetylcholine both cause a postsynaptic excitatory current in inspiratory‐ activated AVPNs, and enhance both the excitatory and inhibitory synaptic inputs. The overall effect of nicotine on inspiratory‐activated AVPNs is excitatory. The nicotinic effects on inspiratory‐activated AVPNs are mediated presynaptically by activation of α4β2 type of nAChRs and postsynaptically by activation of multiple nAChRs including α7 and α4β2 types.