REDfly:: A regulatory element database for Drosophila
REDfly:: A regulatory element database for Drosophila
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DOI：
10.1093/bioinformatics/bti794
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发表时间：
2006-02-01
期刊：
影响因子：
5.8
通讯作者：
Halfon, MS
中科院分区：
文献类型：
--
作者：
Gallo, SM;Li, L;Halfon, MS
后生动物转录调控的生物信息学研究因缺乏大量转录顺式调控模块（CRM）的现成数据而受到严重阻碍。即使是注释丰富的黑腹果蝇基因组也缺乏广泛的CRM信息。因此，我们在此展示一个从文献中整理的果蝇CRM数据库，其中包含DNA序列以及对每个CRM所调控的基因表达模式的可搜索描述。这一资源应极大地促进CRM发现的计算方法的发展以及调控序列特性和进化的生物信息学分析。
Bioinformatics studies of transcriptional regulation in the metazoa are significantly hindered by the absence of readily available data on large numbers of transcriptional cis-regulatory modules (CRMs). Even the richly annotated Drosophila melanogaster genome lacks extensive CRM information. We therefore present here a database of Drosophila CRMs curated from the literature complete with both DNA sequence and a searchable description of the gene expression pattern regulated by each CRM. This resource should greatly facilitate the development of computational approaches to CRM discovery as well as bioinformatics analyses of regulatory sequence properties and evolution.